The birth of boys and girls is actually the the final say of men. If the Y chromosome in the male sex chromosome can be combined with the X chromosome in the female sex chromosome, it is a boy. This sex chromosome not only determines a child's gender, but also their intelligence and physical development. If there is a sex chromosome abnormality, will we have children?
Whether or not to have children due to sex chromosome abnormalities
If there are sexual chromosome abnormalities, it is best not to have children. Even if a child is born, it will be malformed and the survival rate is not very high. For example, children born may have various deformities, such as low body length, low muscle tone, prominent craniofacial deformities, small and round head, flat occipital region, round and flat face, flat nose, thin and tilted face, wide eye distance, obvious epicanthal folds, and often oblique vision.
What happens to sex chromosome abnormalities
1. A woman missing an X - Turner syndrome
The most common chromosomal karyotype in Turner syndrome patients is 45, XO， That is, one X chromosome is missing, accounting for about 50% of the total number of Turner syndrome patients; Chimeric karyotype 45, XO/46,XX， About 25%. In addition, structural abnormalities of the X chromosome, such as long or short arm deletions, isoarm chromosomes, and circular chromosomes, can also cause the occurrence of this disease. The probability of occurrence in newborn female infants is about 1 in 2500.
2. A woman with an additional X - Hyperestrous Syndrome
Super female syndrome, also known as super X syndrome, is the most common female trisomy syndrome. The karyotype is mostly 47, XXX， There are also a few with 48, XXXX or even 49, XXXXX; The incidence rate of female infants is about 1 in 1000.
This type of patient is closely related to the advanced age of the mother. Most patients only show mild symptoms or no obvious symptoms, and 90% of patients have normal fertility and normal survival.
3. Male with an additional X - Klinefelter syndrome
Klinefelter syndrome, abbreviated as "Klinefelter syndrome", is also known as "congenital testicular hypoplasia syndrome" in medicine. Klinefelter's syndrome is a congenital disease caused by an increase in the number of X sex chromosomes, with a majority of chromosomes having a karyotype of 47, XXY， A few are 48, XXXY or 49, XXXXY。
4. Male with an additional Y - Hyperandrogenic Syndrome
Hyperandrogenism, also known as hypermasculinization or excessive masculinization, refers to the appearance of an additional Y chromosome with a karyotype of 47, XYY， The incidence rate can reach 1/1000.
The phenotype of hyperandrogenism is often characterized by tall stature in clinical practice, often exceeding 180cm in height, with normal or slightly reduced intelligence levels; Some patients have a violent temper and are easily agitated; Most of them are fertile and have a normal lifespan.
If sexual chromosome abnormalities are found through examination, it is best not to have children to avoid causing greater harm. In order to achieve the goal of eugenics and good parenting, it is necessary to undergo a physical examination before marriage in order to timely understand the physical condition of both men and women, and to see if there are any genetic diseases or diseases that are not suitable for pregnancy.
