Antisperm antibodies belong to a type of immunological infertility. Antisperm antibodies are a complex pathological product that can affect both men and women, and the exact cause is not yet fully understood. Male sperm and seminal plasma are specific antigens for females. When exposed to blood, both males and females can trigger an immune response, producing corresponding antibodies that hinder the binding of sperm and egg, leading to infertility. Getting weakly positive for anti sperm antibodies greatly reduces the chance of pregnancy.
Antisperm antibodies can affect fertility. Antisperm antibodies bind to cervical mucus proteins to prevent sperm from passing through the cervical mucus. Anti sperm antibodies can interfere with sperm capacitation and acrosome reaction, affecting sperm movement. Cytotoxic effect, mediated by complement, engulfs sperm. Anti sperm antibodies can prevent sperm egg binding, causing complement mediated dissolution of fertilized eggs, damaging embryo implantation and early embryo development, and leading to early miscarriage.
AsAb is an anti sperm antibody, negative is normal, positive is abnormal. Once anti sperm antibodies are present in a woman's body, it can lead to infertility, miscarriage, or termination of pregnancy. The treatment method is to use condoms to separate the sperm from the female partner, without producing new anti sperm antibodies, and the existing antibodies can gradually disappear. This process is quite lengthy, taking at least six months. In addition, low-dose corticosteroids such as prednisone, dexamethasone, and methylprednisolone can be taken orally to suppress immune responses, usually for more than 3 months. The man also needs to be checked. The main examination is AsAb.
A weak positive anti sperm antibody indicates that the condition is not too severe. Therefore, as long as you follow the doctor's advice and reduce contact with sperm, you can generally recover within three months and start preparing for pregnancy!
