As we all know, babies are born in the mother's uterine cavity, surrounded by amniotic fluid, and the development of the fetus can be understood through some substances in the amniotic fluid in the amniotic cavity. Therefore, amniocentesis technology is also available in medicine. So, is it accurate to perform a 28 week amniocentesis on a sheep?
Amniotic fluid aspiration is used to detect fetal chromosomal abnormalities, which can detect all fetal DNA and fully cover the relevant content of non-invasive DNA testing. There are no abnormalities in sheep hybridization, indicating that the fetal genes are not abnormal, which can rule out trisomy syndrome. Usually, chips are not required in this situation. If a problem is found, a chip needs to be made, and the original amniotic fluid can continue to be used. Amniotic fluid aspiration is a minor surgery that is very safe. If the original amniotic fluid is insufficient, the amniotic membrane can be reused.
Generally, amniocentesis mainly analyzes the number of chromosomal aberrations and the deletion, replication, and translocation of fragments, but generally cannot detect small fragment deletions or duplications. However, gene chips can detect small copies or deletions of chromosome fragments, but chromosomal translocations with increased or decreased fragments cannot be detected because these two are usually complementary.
In fact, amniocentesis technology is mainly used to detect some abnormalities in fetal chromosomes and is a supplement to gene chip testing. However, if the fetal development is normal, amniocentesis is unnecessary. Although amniocentesis is only a minor surgery, it can also harm the fetus.
